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. 2021 Jun 1;12(3):718–725. doi: 10.14336/AD.2021.0429

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copyright: © 2021 Zheng et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Post-acute COVID-19 sequelae in multiple organ systems and the expression of ACE2 and TMPRSS2. Human body plot illustrates organ systems affected by post-acute COVID-19 sequelae, with color coding according to the excess burdens of sequelae. Sankey plot shows the relationships among post-acute COVID-19 sequelae, involved organ systems, and expression of ACE2 and TMPRSS2. Node size shows the excess burden of clinical outcome per 1000 participants at 6-months in COVID-19 cases compared to the US VHA (Veteran Health Administration) users. Star shape and color show the status of ACE2 and TMPRSS2 expression in related tissues and cell-type clusters.