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. 2021 May 7;15:618393. doi: 10.3389/fncel.2021.618393

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Copyright 2021 Yeates and Frank.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An electrophysiology screen in a PHD-challenged genetic background. (A) Crossing scheme for generating larvae for electrophysiological recording. Each animal recorded had a homeostatic challenge provided by VGlut overexpression and a concurrent heterozygous or RNAi condition. Fly artwork reproduced from Brusich et al. (2015) under a Creative Commons Attribution License. (B) Data distribution for screened conditions (x-axis = average EPSP for condition; y-axis = average QC for condition). Green = UAS-VGlut, OK371-Gal4/+. Red = UAS-VGlut, OK371-Gal4/RyR^E4340K; itpr^{90 B}/+. Purple = UAS-VGlut, OK371-Gal4/+; UAS-Smn[RNAi]^JF02057/+. Dotted line: EPSP value two standard deviations below UAS-VGlut, OK371-Gal4/+ chosen as a cut off for potential follow-up hits. (C) Average EPSPs for screened conditions. All conditions have a UAS-VGlut, OK371-Gal4/+genetic background. > denotes as UAS construct or RNAi line being driven in motor neurons by OK371-Gal4. + denotes additional mutations present as heterozygotes. Top dotted line denotes UAS-VGlut, OK371-Gal4/+ average. Bottom dotted line denotes two standard deviations below UAS-VGlut, OK371-Gal4/+ average.