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. 2021 May 7;15:618393. doi: 10.3389/fncel.2021.618393

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Copyright 2021 Yeates and Frank.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Additional pharmaco-genetic combinations phenocopy the genetic conditions. (A) Raw data for mEPSPs (left); raw data for EPSPs (middle); raw data for QC (right) for untreated genotypes as shown; bars are averages and error bars are SEM. (B) Data as in (A) but with 25 M Dantrolene added to NMJ preps. (C) Data as in (A) but with 20 M Xestospongin C added to NMJ preps. (D) Representative EPSP traces. Scale bars are as in Figure 1. *p < 0.05, **p < 0.01, and ***p < 0.001 by Students t-test comparing a control dataset (no VGlut overexpression) vs. an experimental dataset (VGlut overexpression).