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. 2021 May 13;18:E45. doi: 10.5888/pcd18.200278

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Preventing Chronic Disease is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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The 4 figures show a linear inverse dose–response association between high-density lipoprotein cholesterol level and risk of total stroke and subarachnoid hemorrhage, a nonlinear inverse dose–response association for ischemic stroke risk, but a linear positive dose–response association for intracerebral hemorrhage risk. — Linear dose–response association between high-density lipoprotein cholesterol and risk of stroke and stroke subtypes modeled with restricted cubic splines. Graph A shows total stroke; B, ischemic stroke; C, intracerebral hemorrhage; and D, subarachnoid hemorrhage.