Fig 7. Antiviral drugs stabilize the vasculature and reduce mortality after SFTSV infection in vivo.

(A) Antiviral drugs anisomysin and vitexicarpin inhibited the viral replication. (B) Anisomysin and vitexicarpin reduced vascular permeability in the lungs. (C) Anisomysin and vitexicarpin stabilized the significant change in the body weight of mice in vivo (D-G) Kinetics of hematological and biochemical parameters in virus infected mice following treated with antiviral drugs were performed at the indicated time points until animals were euthanized. In each graph, gray shadows indicate the physiological reference range of the parameter according to the virus uninfected mice. (H) Immunohistochemistry staining showed that antiviral drugs improved the pathological condition in lung and kidney tissues of SFTSV infected mice. The Scale bars in H&E images are 20 μm. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CREA, creatinine; CK, creatine kinase. Data are shown as mean±SEM of three independent experiments. (*p <0.05, **p <0.01).