Table 2. Basic information about SNPs in COL6A4P2 and association with risk of lung cancer in allele model.
| Gene | SNP ID | Chr. | Alleles(A/B) | Frequency (MAF) | p-value for HWE | OR (95% CI) | p | Function | |
|---|---|---|---|---|---|---|---|---|---|
| Case | Control | ||||||||
| COL6A4P2 | rs34445363 | 3q22.1 | A/G | 0.217 | 0.180 | 0.879 | 1.26 (1.01–1.58) | 0.038 | Selected eQTL hits |
| COL6A4P2 | rs7625942 | 3q22.1 | A/G | 0.223 | 0.225 | 0.608 | 0.98 (0.80–1.21) | 0.915 | Motifs changed, Selected eQTL hits |
| COL6A4P2 | rs77941834 | 3q22.1 | A/T | 0.122 | 0.097 | 0.798 | 1.29 (0.97–1.71) | 0.086 | Motifs changed, Selected eQTL hits |
| COL6A4P2 | rs61733464 | 3q22.1 | A/G | 0.186 | 0.213 | 0.346 | 0.85 (0.68–1.06) | 0.146 | DNAse, Motifs changed, Selected eQTL hits |
| COL6A4P2 | rs11914893 | 3q22.1 | A/C | 0.108 | 0.115 | 0.825 | 0.93 (0.70–1.23) | 0.620 | Motifs changed, GRASP QTL hits |
SNP = single nucleotide polymorphism; Chr. = chromosome; A/B = minor/major, MAF = minor allele frequency; HWE = Hardy Weinberg equilibrium.
p < 0.05 indicates statistical significance.
Bold values indicate a significant difference.