TABLE 1.

List of annotated proteases of Borrelia burgdorferi^a

Gene	Locus	Protein	Protease family	Molecular function
lepB (1)	BB_0031	LepB signal peptidase I	Serine-type endopeptidase	Cleavage of signal/leader peptides
map 1	BB_0067	MAP 1	Metalloprotease aminopeptidase	Unassigned peptidases (methionyl aminopeptidase I family)
Ap II	BB_0069	Aminopeptidase II	Metalloprotease	Putative peptidases
htrA	BB_0104	HtrA	Serine endopeptidases	Periplasmic serine protease (Deg family)
map	BB_0105	Methionine aminopeptidase	Metalloprotease	Removes the N-terminal methionine from nascent proteins
rseP	BB_0118	RseP	Metalloprotease	Putative sigma E protease
cym1	BB_0228	Cym1	Zinc metalloprotease	Putative presequence peptidase
pepF	BB_0248	PepF	Serine-type peptidase	Oligopeptidase F
lon1	BB_0253	Lon (La) ATP-dependent protease	Serine-type peptidase	ATP-dependent cleavage of peptide bonds with broad specificity; actual substrates in Borrelia are not known
lepB (2)	BB_0263	LepB signal peptidase I	Serine-type endopeptidase	Cleavage of signal/leader peptides
hslU	BB_0295	HslU ATP-dependent chaperone	ClpYQ (HslUV)	ATPase component of the HslUV system; cleavage of peptide bonds with broad specificity
hslV	BB_0296	HslV peptidase	Threonine-type endopeptidase activity	Peptidase component of the HslUV system; cleavage of peptide bonds with broad specificity
cptA	BB_0359	CptA	Serine-type endopeptidase	Putative carboxypeptidase
apeA	BB_0366	ApeA	Putative aspartyl aminopeptidase	Putative aminopeptidase
clpA	BB_0369	ClpA ATP-dependent chaperone		ATP-dependent cleavage of peptide bonds with broad specificity; actual substrates in Borrelia are not known
lspA	BB_0469	LspA signal peptidase II	Aspartic-type endopeptidase	Prolipoprotein signal peptides, signal peptidase II
pqqL	BB_0536	PqqL	Zinc metalloprotease	Putative insulinanse family member
Unassigned	BB_0592		Glutamate-type endopeptidase	Putative prenyl-processing peptidase family I
lon2	BB_0613	Lon 2 (La) ATP-dependent protease	Serine-type endopeptidase	ATP-dependent cleavage of peptide bonds with broad specificity; actual substrates in Borrelia are not known
clpP1	BB_0611	ClpP peptidase	Serine-type endopeptidase	ATPase component of the ClpXP system; cleavage of peptide bonds with broad specificity; Actual substrates in Borrelia are not known
clpX	BB_0612	ClpX ATP-dependent chaperone		Peptidase component of the ClpX/A/C systems; cleavage of peptide bonds with broad specificity
pepX	BB_0628	PepX/ApeB	Aspartyl-aminopeptidase	Aminopeptidase family member
clpP2	BB_0757	ClpP2 peptidase	Serine-type endopeptidase	Peptidase component of the ClpX/A/C systems; cleavage of peptide bonds with broad specificity
prp	BB_0779	Prp	Cysteine-type endopeptidase	Ribosomal-processing cysteine protease
ftsH	BB_0819	FtsH ATP-dependent protease	Zinc metalloprotease	Degrades misassembled membrane proteins and cytoplasmic regulatory proteins, including σ32, LpxC, and λCII
clpC	BB_0834	ClpC ATP-dependent chaperone		ATP-dependent cleavage of peptide bonds with broad specificity; actual substrates in Borrelia are not known

^aThe genomes of relapsing fever Borrelia species B. hermsii and B. duttonii carry annotated copies of the genes listed in this table.