TABLE 1.
Summary of gene products associated with antimicrobial resistance, metal/biocide resistance, virulence, partition/maintenance, conjugal transfer, and gene transfer detected in fully sequenced IncI1 plasmids
| Function | Product |
|---|---|
| Antimicrobial resistance | Aminoglycoside N-acetyltransferase AAC(3)-I |
| Aminoglycoside N-acetyltransferase AAC(3)-II | |
| Aminoglycoside acetyltransferase AacC | |
| Aminoglycoside adenyltransferase AadA1 | |
| Aminoglycoside adenyltransferase AadA2 | |
| Aminoglycoside 3′-phosphotransferase APH(3′)-I | |
| Aminoglycoside N-acetyltransferase III ACC(3)-III | |
| Aminoglycoside N-acetyltransferase AAC(3)-VIa | |
| Aminoglycoside O-phosphotransferase APH(3′)-II | |
| Aminoglycoside O-phosphotransferase APH(6)-Ic | |
| Hygromycin resistance protein Hrp | |
| Streptomycin phosphotransferase protein StrA | |
| Streptomycin phosphotransferase protein StrB | |
| Chloramphenicol efflux MFS transporter CmlA | |
| Chloramphenicol/florfenicol efflux MFS transporter FloR | |
| Extended-spectrum beta-lactamase SHV-12 | |
| Extended-spectrum beta-lactamase CTX-M-1 | |
| Extended-spectrum beta-lactamase CTX-M-3 | |
| Extended-spectrum beta-lactamase CTX-M-8 | |
| Extended-spectrum beta-lactamase CTX-M-14 | |
| Extended-spectrum beta-lactamase CTX-M-15 | |
| Extended-spectrum beta-lactamase CTX-M-55 | |
| Extended-spectrum beta-lactamase CTX-M-123 | |
| Class C beta-lactamase CMY-2 | |
| Class C beta-lactamase CMY-4 | |
| Class C beta-lactamase CMY-42 | |
| Class C beta-lactamase CMY-111 | |
| Beta-lactamase, TEM-1 | |
| Beta-lactamase, TEM-20 | |
| Beta-lactamase, TEM-52 | |
| Beta-lactamase, TEM-57 | |
| Beta-lactamase, TEM-210 | |
| Oxacillin-hydrolyzing class D beta-lactamase OXA-2 | |
| Dihydrofolate reductase DhfrA1 | |
| Dihydrofolate reductase DfrA17 | |
| Dihydropteroate synthase type-1 Sul1 | |
| Dihydropteroate synthase type-2 Sul2 | |
| Fosfomycin resistance glutathione transferase FosA3 | |
| Macrolide ABC transporter permease/ATP-binding protein MacB | |
| Macrolide 2′-phosphotransferase MphB | |
| Tetracycline resistance MFS efflux pump TetA | |
| Tetracycline efflux MFS transporter TetC | |
| Tetracycline resistance ribosomal protection protein TetM | |
| Tetracycline resistance transcriptional regulator TetR | |
| Metal/biocide resistance | Arsenical pump-driving ATPase ArsA |
| Arsenical efflux pump membrane protein ArsB | |
| Arsenate reductase ArsC | |
| Arsenical resistance operon transcriptional repressor ArsD | |
| Arsenical resistance operon transcriptional regulator ArsR | |
| Mercuric ion reductase MerA | |
| Organomercurial lyase MerB | |
| Mercuric transport protein MerC | |
| Mercuric resistance operon coregulator MerD | |
| Mercuric transporter protein MerE | |
| Mercuric transcriptional regulator MerR | |
| Quaternary ammonium compound efflux SMR transporter QacE | |
| Quaternary ammonium compound resistance protein QacH | |
| Quaternary ammonium compound resistance protein SugE | |
| Silver- or copper-binding protein SilE | |
| Virulence | Colicin 1B Cib |
| Colicin 1B immunity protein Cbi | |
| Colicin Ia immunity protein Cia | |
| Colicin Ia protein Cai | |
| Colicin M activity protein Cma | |
| Colicin M immunity protein Cmi | |
| CS1 fimbrial subunit A CfaA | |
| CS1 fimbrial subunit B CfaB | |
| Plasmid-encoded fimbriae Pef | |
| Partition/maintenance | Stable plasmid inheritance protein A ParA |
| Stable plasmid inheritance protein B ParB | |
| Plasmid maintenance protein CcdA | |
| Plasmid maintenance protein CcdB | |
| Plasmid maintenance protein VagD | |
| Plasmid maintenance protein VagC | |
| Plasmid maintenance protein PndA | |
| Plasmid maintenance protein PndB | |
| Plasmid maintenance protein PndC | |
| Plasmid maintenance protein RelB | |
| Plasmid maintenance protein RelE | |
| Conjugal transfer | Conjugal transfer protein TraA |
| Conjugal transfer transcription antiterminator TraB | |
| Conjugal transfer protein TraC | |
| Conjugal transfer system coupling protein TraD | |
| Conjugal transfer protein PilI | |
| Conjugal transfer protein PilJ | |
| Conjugal transfer protein PilK | |
| Conjugal transfer outer membrane protein PilL | |
| Conjugal transfer protein PilM | |
| Conjugal transfer protein PilN | |
| Conjugal transfer protein PilO | |
| Conjugal transfer pilus biogenesis protein PilP | |
| Conjugal transfer protein PilQ | |
| Conjugal transfer pilus biogenesis protein PilR | |
| Conjugal transfer pilus biogenesis protein PilS | |
| Conjugal transfer lytic transglycosylase PilT | |
| Conjugal transfer peptidase PilU | |
| Conjugal transfer pilus-tip adhesin protein PilV | |
| Conjugal transfer pilus assembly protein PilX | |
| Conjugal transfer pilus assembly protein TraE | |
| Conjugal transfer protein TraF | |
| Conjugal transfer protein TraG | |
| Conjugal transfer pilus assembly protein TraH | |
| Conjugal transfer lipoprotein TraI | |
| Conjugal transfer protein TraJ | |
| Conjugal transfer protein TraK | |
| Conjugal transfer pilus assembly protein TraL | |
| Conjugal transfer protein TraM | |
| Conjugal transfer protein TraN | |
| Conjugal transfer protein TraO | |
| Conjugal transfer protein TraP | |
| Conjugal transfer protein TraQ | |
| Conjugal transfer protein TraR | |
| Conjugal transfer protein TraS | |
| Conjugal transfer protein TraT | |
| Conjugal transfer pilus assembly protein TraU | |
| Conjugal transfer protein TraV | |
| Conjugal transfer pilus assembly protein TraW | |
| Conjugal transfer pilus acetylation protein TraX | |
| Conjugal transfer integral membrane protein TraY | |
| Conjugal transfer protein TrbA | |
| Conjugal transfer protein TrbB | |
| Conjugal transfer protein TrbC | |
| Conjugal transfer oriT-specific DNA-binding protein NikA | |
| Conjugal transfer relaxase protein NikB | |
| Conjugal transfer protein FinQ | |
| Gene transfer | Insertion element IS1 protein InsA |
| Insertion element IS1 protein InsB | |
| IS629 element | |
| IS100 element | |
| IS4321 element | |
| IS200 element | |
| IS256 element | |
| IS26 element | |
| IS3 element | |
| IS4 element | |
| IS481 element | |
| ISEcp1 element | |
| IS1294 element | |
| IS5 element | |
| IS6 element | |
| IS630 element | |
| IS66 element | |
| IS91 element | |
| ISKra4 element | |
| ISL3 element | |
| Class 1 integron integrase IntI1 | |
| Tn21 protein Urf2 | |
| Tn3 transposase |