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. 2021 May 7;12:650283. doi: 10.3389/fphar.2021.650283

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Copyright © 2021 Li, Zou, Fu, Xing, Wang, Wan, Wang and Zhai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ibudilast administration decreased the expression of pyroptotic markers (IL-1β and IL-18) in mice with FA-induced AKI. (A) Immunohistochemical labeling for IL-1β, bar = 50 μm. (B) Western blot showing the levels of pro-IL-1β and IL-1β. (C) Semiquantitative measurements of IL-1β. (D) Relative mRNA expression of IL-1β. (E) Immunofluorescence staining for IL-18, bar = 50 μm. (F) Western blot of pro–IL-18 and IL-18. (G) Semiquantitative measurements of IL-18. (H) Relative mRNA expression of IL-18. Data are presented as the mean ± SEM, n = 5. *p < 0.05, **p < 0.01, and ***p < 0.001.