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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Shock. 2021 Mar 1;55(3):349–356. doi: 10.1097/SHK.0000000000001639

Figure 1: ERK1/2 inhibitor augments LPS-induced production of IL-6 and VCAM-1, but not IL-8 or PAI-1 by HMVEC.

Figure 1:

HMVEC were pre-treated with ERK1/2 inhibitor (SCH772984; 1μM), or vehicle for 1 hour, and then with LPS (10 ng/ml) for another 6 hours in the continued presence of ERK1/2 inhibitor or vehicle. Levels of (A) IL-6, (B) VCAM-1, (C) IL-8, and (D) PAI-1 were quantified in culture supernatants. n = 4; *p≤0.05; NS, not significant.