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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Shock. 2021 Mar 1;55(3):349–356. doi: 10.1097/SHK.0000000000001639

Figure 4: ERK1/2 inhibitor decreased LPS-induced IL-6, TNFα, IL-8, and IL1β production by human monocytes.

Figure 4:

Primary human CD14+ monocytes were pretreated for 1 hour with ERK1/2 inhibitor (1 μM) and then stimulated with LPS (1 μg/ml) for 6 hours in the continued presence of ERK1/2 inhibitor or vehicle. Levels of (A) IL-6, (B) TNFα, (C) IL-8 and (D) IL1β were quantified in culture supernatants. n = 6; *p≤0.05; NS, not significant.