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. 2021 May 21;7(21):eabg5628. doi: 10.1126/sciadv.abg5628

Fig. 5. V2R and OTR binding pockets: Binding of AVP versus retosiban.

Fig. 5

AVP binding poses are viewed from the side of the V2R helix bundle in L (A) or T (B) state and are compared with that of retosiban (in white sticks) in OTR (C). Receptor residues directly interacting with the ligands (at a maximum of 5 Å in distance) are indicated (Ballesteros-Weinstein numbering). In the OTR, L1203.33 (highlighted in red) is a mutation introduced in the sequence to increase thermostability and facilitate crystallogenesis (V120L). Densities of V2R residues in contact with AVP are shown in L (D) and T (E) states, respectively. (F) Residues of V2R and OTR involved in the binding of ligands are shown in receptor snake-like plot representations (https://gpcrdb.org).