Table 3.
Subgroup analysis of outcomes based on the surgical extents.
| Outcomes | Included studies | Sample size | I2 | Pooled mode | Pooled effect | P value |
|---|---|---|---|---|---|---|
| Operation time | ||||||
| All | 16 | 1975 | 93.7% | Random | WMD:19.33(-1.67,40.34) | 0.07 |
| Minor resection | 9 | 1351 | 93.9% | Random | WMD:14.80(-11.24,40.85) | 0.27 |
| Major resection | 5 | 448 | 84.7% | Random | WMD:47.24(5.52,89.00) | 0.03 |
| Blood loss | ||||||
| All | 15 | 1853 | 57.0% | Random | WMD:-69.16(-101.72,-36.61) | <0.01 |
| Minor resection | 9 | 1351 | 34.3% | Fixed | WMD:-84.75(-112.22,-57.29) | <0.01 |
| Major resection | 4 | 326 | 0.0% | Fixed | WMD:-1.97(-65.34,61.40) | 0.95 |
| Transfusion | ||||||
| All | 10 | 1381 | 7.3% | Fixed | OR:0.63(0.40,1.00) | 0.05 |
| Minor resection | 4 | 823 | 0.0% | Fixed | OR:0.52(0.27.1.02) | 0.06 |
| Major resection | 4 | 382 | 0.0% | Fixed | OR:0.71(0.34,1.49) | 0.36 |
| LOH | ||||||
| All | 16 | 1975 | 69.4% | Random | WMD:-2.65(-3.41,-1.89) | <0.01 |
| Minor resection | 9 | 1351 | 70.8% | Random | WMD:-2.45(-3.33,-1.57) | <0.01 |
| Major resection | 5 | 448 | 4.6% | Random | WMD:-2.99(-4.11,-1.86) | <0.01 |
| Overall complication | ||||||
| All | 15 | 1859 | 0.0% | Fixed | OR:0.57(0.46,0.71) | <0.01 |
| Minor resection | 9 | 1351 | 0.0% | Fixed | OR:0.61(0.48,0.78) | <0.01 |
| Major resection | 5 | 448 | 0.0% | Fixed | OR:0.47(0.30,0.75) | <0.01 |
| Minor complication | ||||||
| All | 8 | 1295 | 0.0% | Fixed | OR:0.70(0.53,0.94) | 0.02 |
| Minor resection | 6 | 1099 | 0.0% | Fixed | OR:0.76(0.55,1.03) | 0.08 |
| Major resection | 2 | 196 | 0.0% | Fixed | OR:0.41(0.18,0.95) | 0.04 |
| Major complication | ||||||
| All | 10 | 1467 | 0.0% | Fixed | OR:0.52(0.33,0.82) | <0.01 |
| Minor resection | 7 | 1215 | 0.0% | Fixed | OR:0.57(0.34,0.94) | 0.03 |
| Major resection | 2 | 196 | 0.0% | Fixed | OR:0.54(0.19,1.56) | 0.26 |
| Mortality | ||||||
| All | 10 | 1425 | 0.0% | Fixed | OR:0.27(0.11,0.66) | <0.01 |
| Minor resection | 6 | 1063 | 0.0% | Fixed | OR:0.26(0.08,0.83) | 0.02 |
| Major resection | 3 | 306 | 0.0% | Fixed | OR:0.34(0.06,1.94) | 0.22 |
| POLF | ||||||
| All | 10 | 1352 | 0.0% | Fixed | OR:0.60(0.38,0.95) | 0.03 |
| Minor resection | 5 | 914 | 0.0% | Fixed | OR:0.63(0.33,1.21) | 0.17 |
| Major resection | 4 | 382 | 0.0% | Fixed | OR:0.60(0.31,1.17) | 0.14 |
| Ascites | ||||||
| All | 11 | 971 | 0.00% | Fixed | OR:0.44(0.28,0.72) | <0.01 |
| Minor resection | 7 | 663 | 0.00% | Fixed | OR:0.48(0.27,0.86) | 0.01 |
| Major resection | 3 | 252 | 0.00% | Fixed | OR:0.43(0.18,1.02) | 0.05 |
| 1-year OS | ||||||
| All | 11 | 1367 | 32.90% | Fixed | HR:0.48(0.31,0.73) | <0.01 |
| Minor resection | 7 | 985 | 0% | Fixed | HR:0.42(0.26,0.68) | <0.01 |
| Major resection | 4 | 382 | 36.4% | Fixed | HR:0.72(0.30,1.74) | 0.46 |
| 2-year OS | ||||||
| All | 12 | 1433 | 0.00% | Fixed | HR:0.61(0.45,0.83) | <0.01 |
| Minor resection | 7 | 985 | 0% | Fixed | HR:0.59(0.42,0.85) | <0.01 |
| Major resection | 5 | 448 | 31.7% | Fixed | HR:0.66(0.37,1.17) | 0.16 |
| 5-year OS | ||||||
| All | 7 | 1127 | 31.70% | Fixed | HR:0.67(0.53,0.85) | <0.01 |
| Minor resection | 5 | 885 | 35% | Fixed | HR:0.69(0.53,0.90) | <0.01 |
| Major resection | 2 | 242 | 55.8% | Random | HR:0.57(0.26,1.30) | 0.18 |
| 1-year DFS | ||||||
| All | 11 | 1387 | 59.70% | Random | HR:0.73(0.52,1.04) | 0.08 |
| Minor resection | 6 | 939 | 67.10% | Random | HR:0.63(0.41,0.96) | 0.03 |
| Major resection | 5 | 448 | 22.3% | Fixed | HR:1.03(0.69,1.56) | 0.88 |
| 2-year DFS | ||||||
| All | 11 | 1387 | 0% | Fixed | HR:0.86(0.73,1.02) | 0.08 |
| Minor resection | 6 | 939 | 0% | Fixed | HR:0.87(0.72,1.05) | 0.15 |
| Major resection | 5 | 448 | 0% | Fixed | HR:0.83(0.59,1.17) | 0.29 |
| 5-year DFS | ||||||
| All | 6 | 781 | 23.80% | Fixed | HR:0.90(0.75,1.07) | 0.23 |
| Minor resection | 4 | 735 | 0% | Fixed | HR:0.87(0.71,1.06) | 0.16 |
| Major resection | 2 | 242 | 81.9% | Random | HR:0.95(0.37,2.44) | 0.91 |
LOH length of hospitalization, CI confidence interval, WMD weighted mean difference, OR odds ratio, POLF postoperative liver failure, HR hazard ratio, OS overall survival, DFS disease-free survival disease-free survival.