FIG 11.
The rOC/SR903A mutant virus remains avirulent even in the absence of an adequate IFN-1 response. Twenty-two-day-old IFNAR-KO mice received 101.5 TCID50/10 μl of rOC/ATCC, rOC/SG758R, rOC/SR903A, or PBS by the i.c. route. (A) Survival curves of mice over a 21-day period. (B) IFNAR-KO mice were weighed every 2 days over a 21-day period to estimate weight variations, which were expressed as percentages, compared to day 0 (100%). (C) Evaluation of the clinical scores (percentage of mice at each level of the scale) of mice infected by rOC/ATCC, rOC/SG758R, or rOC/SGR903A based on neurological symptoms described in a clinical score scale between level 0 and 4 (see Materials and Methods).