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Mutation at either S1/S2 or S2′ site delays viral neuroinvasiveness and propagation within discrete regions of the brain. Ten-day-old C57BL/6 mice received 103.5 TCID50/10 μl of rOC/ATCC, rOC/SG758R, rOC/SR903A, or PBS by the i.n. route. Different regions of the brain were harvested at 2 (A), 3 (B), and 4 (C) dpi, and viral RNA was quantified by qRT-PCR. Each bar (x axis numbers 1 to 5) represents one single infected mouse, and “mock” represents a mock-infected mouse.
