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. 2021 Apr 26;95(10):e01819-20. doi: 10.1128/JVI.01819-20

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Copyright © 2021 de Vries et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 3 — Antiviral SARS-CoV-2 activity and cytotoxicity of PF-00835231 and GC-376 in A549^+ACE2 cells. Antiviral assay workflow as described in Fig. 2a. (a) PF-00835231 and (b) GC-376 antiviral activity and cytotoxicity in A549^+ACE2 cells infected with SARS-CoV-2 USA-WA1/2020 for 24 h. Representative graphs are shown. (c) PF-00835231 and (d) GC-376 antiviral activity and cytotoxicity in A549^+ACE2 cells infected with SARS-CoV-2 USA/NYU-VC-003/2020 for 24 h. Representative graphs are shown. (e) Representative images of SARS-CoV-2 USA-WA1/2020 syncytium formation at 48 hpi in A549^+ACE2 cells under treatment with 1 μM PF-00835231 or GC-376.