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. 2021 Apr 26;95(10):e01819-20. doi: 10.1128/JVI.01819-20

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Copyright © 2021 de Vries et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 6 — Comparative anti-SARS-CoV-2 activity of PF-00835231 and remdesivir in polarized human airway epithelial cultures (HAEC). To test for antiviral activity, drugs were added to the basolateral chamber, cultures were infected with SARS-CoV-2 from the apical side, and apical washes were collected in 12-h increments to determine viral titers by plaque assay. (a and b) SARS-CoV-2 USA-WA1/2020 infectious titers from HAEC treated with incremental doses of remdesivir (a) or PF-00835231 (b). (c) Representative top views of HAEC at 72 hpi; drug doses, 0.3 μM. Blue, 4′,6-diamidino-2-phenylindole (DAPI; nuclei); cyan, ZO-1 (tight junctions); red, SARS-CoV-2 N protein (infected).