. 2021 Apr 26;95(10):e01819-20. doi: 10.1128/JVI.01819-20

TABLE 2.

Antiviral efficacy and cytotoxicity of PF-00835231 versus GC-376 on A549^+ACE2 cells

Strain or drug	Time (hpi)	EC₅₀ (μM)	95% CI	P value for:		EC₉₀ (μM)	95% CI	CC₅₀ (μM)
Strain or drug	Time (hpi)	EC₅₀ (μM)	95% CI	Drug vs drug^a	Isolate vs isolate^b	EC₉₀ (μM)	95% CI	CC₅₀ (μM)
USA-WA1/2020
PF-00835231	24	0.422	0.0836–2.13	0.978	0.326–2.93	>10
PF-00835231	48	0.344	0.0842–1.404	1.158	0.358–3.74	>10
GC-376	24	0.623	0.257–1.506	0.366	4.55	1.89–10.91	>10
GC-376	48	0.696	0.198–2.44	0.114	5.25	2.53–10.875	>10
USA/NYU-VC-003/2020
PF-00835231	24	0.326	0.098–1.08	0.543	1.17	0.115–11.89	>10
GC-376	24	0.529	0.184–1.512	0.265	0.700	2.734	0.897–8.33	>10

EC₅₀ of GC-376 versus EC₅₀ of PF-00835231.

EC₅₀ of drug versus EC₅₀ of the same drug for USA-WA1/2020.