FIG 1.

Replication and transmission of mammalian-adapted IAVs in a guinea pig model. A total of 12 guinea pigs were inoculated intranasally with the indicated doses of the indicated IAV strains. One naive guinea pig was introduced into the same cage with each inoculated animal at 24 h postinoculation. Viral titers detected in nasal washes are plotted against time (days). The limit of detection is 1.70 log₁₀ PFU/ml, and data below the limit of detection are plotted at 0 log₁₀ PFU/ml. Dashed lines represent inoculated animals, and solid lines show contact animals. N.D., not done. Results obtained with can/IL/15 virus were reported previously (38).