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. 2021 May 10;95(11):e01751-20. doi: 10.1128/JVI.01751-20

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This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 3 — The PRRA insert at the S1/S2 site distinctly modulates cell susceptibility to SARS-CoV-2 pseudovirions. (A to C) Entry of HIV pseudotyped with SARS-CoV-2 S, SARS-CoV-2 S ΔPRRA, bat RaTG13 S, RaTG13 S+PRRA, and pangolin GX S into 293T cells transiently expressing ACE2 (A), Calu-3 cells (B), and Caco-2 cells (C). (D) Western blot analysis of pseudovirions bearing SARS-CoV-2 S, SARS-CoV-2 S ΔPRRA, bat RaTG13 S, RaTG13 S+PRRA, and pangolin GX S. Red, anti-p24 antibody; green, antispike antibody. (E) Infection by pseudovirions harboring the indicated viral glycoproteins in 293T cells transfected with ACE2 alone or in combination with TMPRSS2. Data are presented as means ± SEM. *, P < 0.01.