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. 2021 May 10;95(11):e01751-20. doi: 10.1128/JVI.01751-20

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FIG 4 — The novel S1/S2 site alters the dependence of RaTG13 pseudovirus on ACE2 orthologs. Shown are the infectivities of pseudovirions harboring the indicated viral spike proteins on 293T cells transiently transfected with Chinese hamster ACE2 and bovine ACE2 (A), Syrian hamster ACE2 and human ACE2 (B), ferret ACE2 and pig ACE2 (C), Agm ACE2 and mouse ACE2 (D), and horseshoe bat ACE2 and Malayan pangolin ACE2 (E). Data are presented as means ± SEM. *, P < 0.01; **, P < 0.001; ***, P < 0.0001; ****, P < 0.00001. Numbers above the asterisks denote the fold changes. (F) Binding of pseudovirions carrying SARS-CoV-2 S, RaTG13 S, and RaTG13 S+PRRA to full-length recombinant human and mouse ACE2 was quantified by qPCR (see Materials and Methods). Binding relative to that of bald virus is plotted.