Table 3.

Impact of Predictive Factors on EGFR-TKIs in Univariate and Multivariate Analyses (n = 131)

	Univariate Analysis		Multivariate Analysis
Variables	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value
Age (≥70)	0.877(0.519–1.483)	0.625
Sex (female)	1.052(0.708–1.563)	0.801
Smoking status (smoker)	1.947(1.209–3.138)	0.006	1.882(1.168–3.033)	0.009
ECOG (2)	1.491(0.546–4.070)	0.436
Extra-metastases (positive)	0.859(0.575–1.282)	0.447
Histological subtypes (high-grade patterns)	1.450(0.974–2.159)	0.067	1.395(0.936–2.080)	0.102
EGFR mutations (19DEL)	1.183(0.792–1.768)	0.412
Targeted therapy (Gefitinib)	1.198(0.962–1.491)	0.106
Vascular spread(positive)	1.066(0.661–1.710)	0.794
T stage (T3, T4)	1.317(0.795–2.182)	0.285
Nodal state (N2, N3)	1.166(0.751–1.810)	0.494
Pleural involvement(present)	0.570(0.278–1.171)	0126
Stage (rIV)	1.025(0.496–2.118)	0.946

Abbreviations: ECOG, Eastern Cooperative Oncology Group; 19DEL, exon 19 deletion.