Appendix 1—figure 1. Comparison of the simulations with the experimental images.

(a) Snapshots of simulations for chromatin-chromatin attractions $ϵ=0.5$. For relatively small volume fraction of chromatin ($\varphi =0.1$) and relatively high chromatin-lamina binding interactions ($\psi =0.5$), the simulation shows peripheral organization of chromatin. For $\varphi =0.1$ (small) and $\psi =0.1$ (small), we obtain central organization of chromatin (see Appendix 5 on the wetting droplet). For $\varphi =0.3$ (high) and $\psi =1$ (high), the simulations show conventional organization of chromatin, where the entire nucleus is filled. (b) Different organization of chromatin obtained in the experiments: peripheral, central and conventional are seen in experiments in the control, lamin A/C overexpression and fixed nuclei respectively (Amiad-Pavlov et al., 2020).