Figure 6. Angular separation of LAD and non-LAD chromatin.

(a) Simulation snapshot for parameter values $\psi =1$, $\varphi =0.1$, and $ϵ=0.5$, shows peripheral organization with LAD near lamina and non-LADs separated from LADs in the radial direction. (b) Simulation snapshot for parameter values $\psi =0.5$, $\varphi =0.1$, and $ϵ=0.5$, shows peripheral organization with alternating LAD and non-LAD regions in the angular direction at the nuclear periphery. (c) Experimentally labeled H3K9ac (euchromatin/most of non-LAD/green) and His2B (chromatin/LAD and non-LAD/red) in muscle nuclei of intact Drosophila larvae, shows heterochromatin (associated with LAD) by dark red color and euchromatin (associated with non-LAD) by merging the red and green colors in peripheral organization. Both the experiments and simulations show an angular distribution of LAD and non-LAD as opposed to a radial distribution.