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. 2021 Apr 26;10:e62639. doi: 10.7554/eLife.62639

Table 1. Model parameters.

Parameter Basic model Model with slow inactivation of INap
Passive parameters
Input conductance Gin 1 nS Same
Input capacitance Cin 13 pF (E12.5, Figures 7B, C, D, F and 8B– D) or 18 pF (E14.5, Figure 7G) 13 pF
Resting potential Vr −60 mV Same
Injected current I 20 pA (Figure 7B–G) 10 pA (Figure 8C) or 12 pA (Figure 8D) variable in Figure 8B
Transient sodium current Inat
Maximal conductance GNat 20 nS Same
Reversal potential ENa 60 mV
Activation exponent 3
Mid-activation Vm −26 mV
Steepness of activation km 9.5 mV
Activation time constant 1.5 ms
Mid-inactivation Vh −45 mV
Steepness of inactivation Kh −5 mV
Inactivation time constant τm Voltage-dependent (see Material s and methods)
Persistent sodium current INap
Maximal conductance Variable (see text and figure captions) Same
Mid-activation voltage −36 mV Same
Mid-inactivation Vs −30 mV
Steepness of inactivation ks −5 mV
Inactivation time constant Slow inactivation not included 2 s
Delayed rectifier potassium current IKdr
Maximal conductance GKdr Variable (see text and figure captions) Same
Reversal potential EK −96 mV
Activation exponent 3
Mid-activation Vn −20 mV
Steepness of activation kn 15 mV
Activation time constant τm 10 ms
Potassium A current IA (when included in the basic model)
Maximal conductance GA Equal to GKdr Never included
Mid-activation VmA −30 mV
Steepness of activation kmA 12 mV
Activation time constant Instantaneous activation
Mid-inactivation VhA −70 mV
Steepness of inactivation khA −7 mV
Inactivation time constant τhA 23 ms