Table 2.

Univariate and multi-variate Cox regression analysis

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (≥ 65 vs. < 65 years)	1.09 (0.809 ~ 1.47)	0.57
T stage (T3-T4 vs. T1-T2)	2.28 (1.55 ~ 3.35)	< 0.0001	1.7 (1.06 ~ 2.8)	0.029
N stage (N1-N3 vs. T0)	2.64 (1.96 ~ 3.56)	< 0.0001	2.1 (1.44 ~ 3.2)	< 0.0001
M stage (M1 vs. M0)	2.13 (1.24 ~ 3.65)	0.01	1.4 (0.71 ~ 2.6)	0.34
TNM stage (stage III-IV vs. I-II)	2.63 (1.93 ~ 3.59)	< 0.0001	1.2 (0.73 ~ 2.0)	0.44
Risk score (high vs. low)	2.52 (1.85 ~ 3.43)	< 0.0001	2.2 (1.51 ~ 3.2)	< 0.0001