Table 2.

Correlation of immunologic variables (overall TIL) with morphomolecular data

	Grading (WHO)							Grading (WHO)					p53 status					Microsatellite status					Microsatellite status							POLE status
	G1		G2		G3			Low grade (g1/g2)		High grade (g3)			Mutated		Wildtype			MSI		MSS			MLH1/PMS2 loss		MSH2/MSH6 loss		MSS			Wildtype		Mutated
	n	%	n	%	n	%	p value	n	%	n	%	p value	n	%	n	%	p value	n	%	n	%	p value	n	%	n	%	n	%	p value	n	%	n	%	p value
Overall TIL (CD3)
Low	39	27.5	33	23.2	19	13.4	< 0.001	72	50.7	19	13.4	< 0.001	16	11.3	75	52.8	0.109	25	17.6	66	46.5	0.019	19	13.4	6	4.2	66	46.5	0.007	88	62.0	3	2.1	0.230
High	6	4.2	12	8.5	33	23.2		18	12.7	33	23.2		4	2.8	47	33.1		24	16.9	27	19.0		23	16.2	1	0.7	27	19.0		47	33.1	4	2.8
Overall T-Killer cells (CD8)
Low	31	21.8	23	16.2	7	4.9	< 0.001	54	38.0	7	4.9	< 0.001	11	7.7	50	35.2	0.241	16	11.3	45	31.7	0.072	11	7.7	5	3.5	45	31.7	0.016	59	41.5	2	1.4	0.430
High	14	9.9	22	15.5	45	31.7		36	25.4	45	31.7		9	6.3	72	50.7		33	23.2	48	33.8		31	21.8	2	1.4	48	33.8		76	53.5	5	3.5
Overall regulatory T-cells (FoxP3)
Low	45	31.7	38	26.8	31	21.8	< 0.001	83	58.5	31	21.8	< 0.001	19	13.4	95	66.9	0.074	34	23.9	80	56.3	0.018	27	19.0	7	4.9	80	56.3	0.005	109	76.8	5	3.5	0.546
High	0	0.0	7	4.9	21	14.8		7	4.9	21	14.8		1	0.7	27	19.0		15	10.6	13	9.2		15	10.6	0	0.0	13	9.2		26	18.3	2	1.4