Table 3.

Multivariate statistical analysis for p53-mutant endometrial carcinoma (left side) and endometrial carcinoma with non-specific molecular profile (right side) under inclusion of age, grading, stage and FoxP3 + TIL (in p53-mutant endometrial carcinoma)

Endometrial carcinoma with p53 mutation					Endometrial carcinoma with non-specific molecuar profile (NSMP)
	HR (OS)	Lower CI (95%)	Upper CI (95%)	p value		HR (DSS)	Lower CI (95%)	Upper CI (95%)	p value
Age					Age
Per year	2.755	0.369	20.560	0.323	Per year	0.978	0.310	3.084	0.970
Grading					Grading
1				0.698	Low				0.011
2	> 25	< 0.001	> 25		High	4.329	1.404	13.349
3	> 25	< 0.001	> 25
FIGO Stage					FIGO Stage
Low (I/II)	12.477	0.682	> 25	0.089	Low (I/II)				0.019
High (III/IV)					High (III/IV)	4.375	1.270	15.069
FoxP3 + TIL
Low				0.035
High	49.3	1.315	> 25
	HR (DSS)	Lower CI (95%)	Upper CI (95%)	p value		HR (DFS)	Lower CI (95%)	Upper CI (95%)	p value
Age					Age
Per year	1.791	0.134	23.978	0.660	Per year	1.572	0.561	4.401	0.390
Grading					Grading
1				0.726	Low				0.042
2	> 25	< 0.001	> 25		High	2.778	1.037	7.442
3	> 25	< 0.001	> 25
FIGO Stage					FIGO Stage
Low (I/II)				0.119	Low (I/II)				< 0.001
High (III/IV)	12.377	0.518	> 25		High (III/IV)	8.527	3.144	23.123
FoxP3 + TIL
Low				0.032
High	71.588	1.430	> 25
	HR (DFS)	Lower CI (95%)	Upper CI (95%)	p value
Age
Per year	0.477	0.050	4.506	0.518
Grading
1				0.991
2	> 25	< 0.001	> 25
3	> 25	< 0.001	> 25
FIGO Stage
Low (I/II)				0.029
High (III/IV)	17.238	1.347	> 25
FoxP3 + TIL
Low				0.012
High	147.060	2.976	> 25