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Optimization of the conditions for the [18F]-incorporation into the TFMO moiety.
| Entry | Base | Solvent | Temp. (°C) | Time | %RCY |
|---|---|---|---|---|---|
| 1 | K2CO3 | DMSO | 150 | 25 | < 0.5 |
| 2 | Cs2CO3 | DMSO | 150 | 25 | 3–5 |
| 3 | Cs2CO3 | DMF | 150 | 25 | 0 |
| 4 | Cs2CO3 | DMA | 150 | 25 | 3–5 |
| 5 | Cs2CO3 | Acetonitrile | 150 | 25 | 0 |
