Fig. 2. Receiver operator plots of polygenic risk scores for eight common cancers.

AUC area under the curve. The AUC provides an estimate of the probability a randomly selected subject with the condition has a test result indicating greater than that of a randomly chosen individual without the cancer. The solid line represents a receiver operator curve based on polygenic risk score from known risk SNPs based on reference¹³. An AUC of 0.5 (dashed line) indicates that the classifier does not provide any useful information in discriminating cases from controls.