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. 2021 May 21;4:616. doi: 10.1038/s42003-021-02099-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a UMAP plot of all cells from G-Smo and M-Smo tumors, color-coded by cluster. Cells are localized according to their proximity in PCA space. b, c Feature plots showing expression of b stromal markers, or c cerebellar granule neuron differentiation markers, color-coded over the UMAP shown in a arrow in c indicates the direction of differentiation across the UMAP. d UMAP plots deconvoluted by genotype, with differentially represented clusters color-coded. e Comparison of each cluster population in G-Smo and M-Smo tumors. Dots represent values for individual replicates, bars indicate the means and whiskers indicate the SEM. ** indicates p < 0.01, * indicates p < 0.05; Student’s t-test was used to make the pairwise comparison. f UMAP plots for each genotype, showing expression of the indicated stem cell markers.