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. 2021 May 21;11:10688. doi: 10.1038/s41598-021-89176-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Miami plots of candidate SNPs identified for allometric body-shape indices in women and men. (a) GWAS of waist-to-hip index calibrated for UK Biobank participants (WHI_UKB); (b) GWAS of a body shape index calibrated for UK Biobank participants (ABSI_UKB); (c) GWAS of hip index calibrated for UK Biobank participants (HI_UKB); P-P-values were derived from BOLT-LMM infinitesimal models; SNP-single nucleotide polymorphism; horizontal lines correspond to the genome-wide significance cut-off P = 5*10^–8. Genomic risk loci with their corresponding locus lead SNPs were identified with FUMA v1.3.6a. All candidate SNPs are shown in grey, locus lead SNPs are colour-coded as follows: (grey circle) candidate SNPs; (dark red circle) novel genomic risk locus identified in the current study, with no previously reported candidate SNPs; (orange circle) genomic risk locus with a previously reported locus lead SNP; (yellow circle) genomic risk locus with a previously reported SNP in strong linkage disequilibrium (LD) with the locus lead SNP at r² ≥ 0.6; (cyan circle) genomic risk locus with previously reported other candidate SNP. SNPs identified for allometric body-shape indices in the current study were matched against SNPs reported in the NHGRI-EBI GWAS Catalog¹¹ (https://www.ebi.ac.uk/gwas/home, accessed on 07/04/2021) in association with the corresponding traditional body-shape index (with or without adjustment for body mass index, BMI), i.e. the waist-to-hip ratio for WHI_UKB (catalogue sets EFO_0004343, EFO_0007788, EFO_0004302); waist circumference for ABSI_UKB (EFO_0004342, EFO_0007789, EFO_0004302); hip circumference for HI_UKB (EFO_0005093, EFO_0008039, EFO_0004302).