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. 2021 May 21;11:10688. doi: 10.1038/s41598-021-89176-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene sets associated with allometric body-shape indices. ABSI-a body shape index calibrated for UK Biobank participants (ABSI_UKB); Currated-curated gene set; GO-BP-gene ontology biological process; GO-CC-gene ontology cellular component; GO-MM-gene ontology molecular function; HI-hip index calibrated for UK Biobank participants (HI_UKB); WHI-waist-to-hip index calibrated for UK Biobank participants (WHI_UKB); #-reactome runx1 regulates transcription of genes involved in wnt signaling. The figure includes gene sets identified using competitive gene-set analysis with MAGMA v1.08 employed in FUMA v1.3.6a as significant for at least one of the allometric indices in women or men with adjusted P_adj < 0.05, incorporating Bonferroni correction for multiple comparisons for 15,485 gene sets. Gene sets with P_adj < 0.05 for WHI_UKB in women were sorted in descending order of P_adj, for WHI_UKB in women, then the remaining gene sets with P_adj < 0.05 for WHI_UKB in men were sorted in descending order of P_adj for WHI_UKB in men, then the remaining gene sets with P_adj < 0.05 for HI_UKB in women were sorted in descending order of P_adj for HI_UKB in women and last, the remaining gene sets with P_adj < 0.05 for HI_UKB in men were sorted in descending order of P_adj for HI_UKB in men, leaving a single gene set associated only with ABSI_UKB in women. The horizontal lines mark the start of the next sorting criterion. White cells are gene sets with P_adj ≥ 0.05 for the corresponding body-shape index.