Image Guided Superficial Radiation Therapy (IGSRT) was safe and well tolerated in this study, involving 1632 patients with non-melanoma skin cancer (NMSC). Of 2917 NMSC lesions treated, local tumor control was achieved in 2897 lesions, representing a 99.3% rate of control.

IGSRT should be considered as a first-line option for treating stage 0–II NMSC lesions in suitable patients, especially those who are not candidates for surgery or who decline surgery.

NMSC is a highly prevalent condition, with an estimated annual incidence in the U.S. of 5.5 million tumors in 2012.

This study presents a retrospective evaluation of efficacy and safety of image-guided superficial radiotherapy, a nonsurgical treatment option, in 2917 NMSC lesions (1632 patients).

Treatment with IGSRT resulted in local tumor control in 2897 lesions, representing a 99.3% rate of control.

IGSRT was safe and well-tolerated in this study.

These results suggest IGSRT should be considered as a first-line option for treating NMSC in suitable patients.