Table 3.
AJCC 8th edition for both clinical and pathological staging
| Primary tumor (T) | ||
| T category | T criteria | |
| Tx | Primary tumor cannot be assessed | |
| T0 | No evidence of primary tumor | |
| Tis | Carcinoma in situ [penile intraepithelial neoplasia (PeIN)] | |
| Ta | Noninvasive localized squamous cell carcinoma | |
| T1 |
-Glans: Tumor invades lamina propria -Foreskin: Tumor invades dermis, lamina propria, or dartos fascia -Shaft: Tumor invades connective tissue between epidermis and corpora regardless of location |
|
| T1a | Tumor is without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid) | |
| T1b | Tumor exhibits lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid) | |
| T2 | Tumor invades corpus spongiosum (either glans or ventral shaft) with or without urethral invasion | |
| T3 | Tumor invades corpus cavernosum (including tunica albuginea) with or without urethral invasion | |
| T4 | Tumor invades adjacent structures (i.e., scrotum, prostate, pubic bone) | |
| Regional nodes (N) | ||
| Clinical N category | Clinical N criteria | |
| cNx | Regional lymph nodes cannot be assessed | |
| cN0 | No palpable or visibly enlarged inguinal lymph nodes | |
| cN1 | Palpable mobile unilateral inguinal lymph node | |
| cN2 | Palpable mobile ≥ 2 unilateral inguinal nodes or bilateral inguinal lymph nodes | |
| cN3 | Palpable fixed inguinal nodal mass or pelvic lymphadenopathy unilateral or bilateral | |
| Pathological N | Pathological N criteria | |
| pNx | Lymph node metastasis cannot be established | |
| pN0 | No lymph node metastasis | |
| pN1 | ≤ 2 unilateral inguinal metastases, no ENE | |
| pN2 | ≥ 3 unilateral inguinal metastases or bilateral metastases, no ENE | |
| pN3 | ENE of lymph node metastases or pelvic lymph node metastases | |
| Distant metastasis (M) | ||
| M category | M criteria | |
| M0 | No distant metastasis | |
| M1 | Distant metastasis present | |
| Histologic grade (G) | ||
| Gx | Grade cannot be assessed | |
| G1 | Well differentiated | |
| G2 | Moderately differentiated | |
| G3 | Poorly differentiated/high grade | |
| Prognostic stage groups | ||
| Stage 0 (0is, 0a) | Tis-Ta N0 M0 | |
| Stage I | T1a N0 M0 | |
| Stage IIA | T1b-T2 N0 M0 | |
| Stage IIB | T3 N0 M0 | |
| Stage IIIA | T1-T3 N1 M0 | |
| Stage IIIB | T1-T3 N2 M0 | |
| Stage IV | T4 or/and N3 or/and M1 | |