Table 2.

Regional Effect of HCMV Infection on Gray Matter Volume

IPTW adjusted	Sample 1			Sample 2
ROI	SBCa	95%CIb	p	SBC	95%CI	p
Main effect of HCMV
L pars orbitalis gyrus	−0.38	−0.68 ~ −0.07	0.02	−0.15	−0.56 ~ 0.25	0.47
L fusiform gyrus	−0.25	−0.49 ~ −0.01	0.04	−0.51	−0.80 ~ −0.23	<0.001 ***
L inferior parietal lobule	−0.25	−0.49 ~ −0.01	0.05	−0.06	−0.51 ~ 0.39	0.79
R lateral orbitofrontal gyrus	−0.23	−0.46 ~ −0.01	0.04	−0.21	−0.63 ~ 0.22	0.34
R parahippocampal gyrus	−0.32	−0.62 ~ −0.03	0.03	0.25	−0.06 ~ 0.57	0.12
R supramarginal gyrus	−0.26	−0.51 ~ −0.01	0.04	−0.32	−0.64 ~ −0.01	<0.05 *
HCMV effect in MDD
L pars orbitalis gyrus	−0.37	−0.68 ~ −0.07	0.02	−0.16	−0.57 ~ 0.25	0.44
L fusiform gyrus	−0.25	−0.49 ~ −0.02	0.04	−0.50	−0.77 ~ −0.22	<0.001 ***
L inferior parietal lobule	−0.25	−0.50 ~ −0.01	0.05	−0.07	−0.50 ~ 0.36	0.75
R lateral orbitofrontal gyrus	−0.24	−0.47 ~ −0.01	0.04	−0.22	−0.65 ~ 0.21	0.31
R parahippocampal gyrus	−0.33	−0.63 ~ −0.04	0.03	0.29	−0.06 ~ 0.64	0.10
R supramarginal gyrus	−0.27	−0.53 ~ −0.02	0.04	−0.34	−0.67 ~ −0.01	<0.05 *
HCMV effect in HC
L pars orbitalis gyrus	0.05	−0.51 ~ 0.63	0.86	−0.04	−0.34 ~ 0.27	0.82
L fusiform gyrus	−0.05	−0.52 ~ 0.43	0.84	−0.09	−0.35 ~ 0.18	0.52
L inferior parietal lobule	−0.25	−0.81 ~ 0.31	0.38	−0.02	−0.36 ~ 0.33	0.93
R lateral orbitofrontal gyrus	0.11	−0.32 ~ 0.54	0.61	−0.32	−0.61 ~ −0.03	0.03
R parahippocampal gyrus	−0.11	−0.78 ~ 0.55	0.75	−0.29	−0.62 ~ 0.04	0.08
R supramarginal gyrus	−0.16	−0.79 ~ 0.47	0.62	−0.23	−0.55 ~ 0.09	0.17

Abbreviation: ROI, region of interest; R, right; L, left;

^aStandardized beta coefficient. SBC of 1 indicates that the mean gray matter volume of the HCMV+ subgroup is 1 standard deviation different from the HCMV− subgroup. A negative value indicates HCMV+ < HCMV−, and a positive value indicates HCMV+ > HCMV−.

^b95%CI, 95% confidence interval, robust standard errors was used to calculate 95%CI.

^*P_uncorrected less than 0.05 in both samples and in the same direction.

^***P_FDR < 0.01