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. 2021 May 21;6:78. doi: 10.1038/s41541-021-00337-0

Fig. 1. Persistence and post-antigen recall responses of HBsAg-specific antibodies, memory B cells, and CD4+ T cells in the Booster Cohort.

Fig. 1

Subjects of the per-protocol Booster Cohort (N = 265) received two doses of hepatitis B surface antigen (HBsAg) vaccine adjuvanted with AS01B, AS01E, AS03, AS04, or Alum at Day (D)0 and D30. They also received revaccination with non-adjuvanted HBsAg, using 1/4th of the adjuvanted antigen dose, at D360. Lines and symbols are color-coded according to the adjuvant groups presented in the key. Presented are the kinetics of geometric mean concentrations (GMC) of anti-HBsAg antibodies with 95% confidence intervals (CI; a), and the kinetics of geometric mean frequencies (GMF) of HBsAg-specific IgG-secreting memory B cells (b) or CD40L+ CD4+ T cells (c).