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. 2021 May 21;11:306. doi: 10.1038/s41398-021-01411-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Manhattan plot of TWAS results in CMC dataset (a total of 33 significant genes detected). b Manhattan plot of TWAS results in BrainSeq2 dataset (a total of 27 significant genes detected). Each point represents a gene, with physical genomic position (chromosome, basepair) plotted on the x-axis and association P-value (the −log₁₀ (FUSION P-value)) between gene expression in the DLPFC and depression plotted on the y-axis. Bonferroni-corrected significant genes are labeled and the significance threshold of P = 7.91 × 10⁻⁶ was used. Seven genes reached transcriptome-wide significance in both two expression panels (including B3GALTL, FADS1, TCTEX1D1, XPNPEP3, ZMAT2, ZNF501 and ZNF502) and are highlighted in red colour.