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. 2021 May 21;11:10681. doi: 10.1038/s41598-021-90111-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamic profiles of clinical signs over time in non-severe patients with COVID-19. In the first week after symptoms onset, COVID-19 patients showed remarkably decreased levels of lymphocyte count and calcium and slightly increased levels of C-reactive protein, lactic dehydrogenase, fibrinogen, and D-dimer. Meanwhile, the levels of albumin, high sensitive troponin I, and pulse oximeter O₂ saturation remained unchanged. All the clinical signs, including lymphocyte count, electrolyte, albumin, high sensitive troponin I, C-reactive protein, lactic dehydrogenase, fibrinogen, D-dimer, and pulse oximeter O₂ saturation, were at the peak (bottom) in the second week after symptoms onset. The majority of clinical signs improved in the third week, whereas C-reactive protein, lactic dehydrogenase, fibrinogen, and D-dimer were still at a relatively high level. All the above indicators were maintained at a significantly low (high) level during the fourth week to the fifth week after symptoms onset. Upper limit of reference interval (red line); Lower limit of reference interval (black line). SPO₂ pulse oximeter O₂ saturation, PLT platelet count, CRP C-reactive protein, LDH lactic dehydrogenase, PT prothrombin time.