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. 2021 May 21;11:10677. doi: 10.1038/s41598-021-90059-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression level of SIRT1 in the peripheral blood of PD patients and healthy controls. Significant down-regulation of SIRT1 expression was measured in PD group compared to controls (A), and in EOPD patients compared to controls (B) as well. No significant difference was detected in the case of EOPD vs. LOPD (C) and LOPD vs. control group (D) comparisons. Fold changes are shown with standard deviation. PD Parkinson’s disease, Ctrl control, EOPD early onset Parkinson’s disease, LOPD late onset Parkinson’s disease, n.s. non-significant; ***p < 0.001 after FDR correction.