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. 2021 May 21;4:607. doi: 10.1038/s42003-021-02094-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Percentage of DMRs with active regulatory annotations (promoter and/or active enhancer) in EAC and GBM. b Overlap of tumor suppressor genes (TSGs) with abnormally methylated core promoters (1 kb, centered around TSS) in EAC and GBM. Left: hyperDMRs (overlap is significant: p < 8.39E − 14, hypergeometric test); right: hypoDMRs. c TSGs with abnormally methylated promoters (1 kb, centered around the TSS) and/or active enhancers in EAC (left) and GBM (right), accompanied by fold change in expression of TSGs in EAC and GBM. NB: normal brain; NE: normal endometrium. Orange and red bars indicate the presence of a DMR within an active enhancer/promoter in EAC and GBM hyperDMRs, respectively. d Top enriched GO terms (Biological Process) of ce-hyperDMRs in EAC (top) and GBM (bottom). Values represent the −log10(Binomial p-value). e Hypermethylation status of apoptosis gene promoters (red) and enhancers (blue) in EAC (left) and GBM (right).