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. 2021 May 21;4:607. doi: 10.1038/s42003-021-02094-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Enhancer annotation (chromHMM 15-state model annotation “7_Enh”³²) presence or absence in GBM hyperDMRs in fetal (n = 6, light blue) and adult brain (n = 7, purple) tissue/cells³² (heatmap colors: blue: enhancer annotation present in DMR; gray: enhancer annotation absent in DMR). Bar plot indicates the fraction of all GBM hyperDMRs overlapping enhancer annotations in each cell/tissue type. b Boxplot depicting the distribution of fractions of GBM hyperDMRs overlapping enhancer annotations, comparing adult (n = 7) and fetal (n = 6) brain tissues (t-test, p < 0.05). c H3K27ac (green) and H3K4me1 (orange) peak occupancy within GBM enhancer-potential hyperDMRs (GBM hyperDMRs overlapping an enhancer annotation in at least one adult or fetal brain tissue) across fetal (n = 1 and 6, for H3K27ac and H3K4me1, respectively, light blue) and adult (n = 7 for both H3K27ac and H3K4me1, purple) brain tissues. Bar plot indicates the fraction of all GBM enhancer-potential hyperDMRs that contained H3K27ac peaks or H3K4me1 peaks in each cell/tissue type. d Boxplot depicting fractions of GBM enhancer-potential hyperDMRs overlapping H3K27ac peaks in adult brain tissues (n = 7, left) and horizontal line depicting the fraction of GBM enhancer-potential hyperDMRs overlapping H3K27ac peaks in fetal brain (n = 1, right). e Comparison of the proportions of GBM enhancer-potential hyperDMRs overlapping H3K4me1 peaks in adult brain tissues (n = 7, left) to the proportions of GBM enhancer-potential hyperDMRs overlapping H3K4me1 peaks in fetal brain tissues (n = 6, right) (t-test, p < 0.01).