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. 2021 May 21;12:3006. doi: 10.1038/s41467-021-23334-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Whole blood from a healthy donor was washed twice with medium to remove the plasma. Plasma from 10 healthy controls (healthy plasma; n = 10 biologically independent samples), 13 non-ventilated (non-vent. plasma; n = 13 biologically independent samples), and 15 mechanically ventilated (vent. plasma; n = 19 biologically independent samples) COVID-19 patients was added and samples were cultured with anti-CD3 for 24 h. In all, 23% of the non-ventilated and 33% of the ventilated COVID-19 patients were treated with steroids (marked in blue). None of the patients was treated with other immunosuppressive agents. Expression of indicated surface markers was quantified by flow cytometry on basophils, CD14 + monocytes and neutrophils. The absolute expression values of indicated markers are shown as mean fluorescence intensity (MFI) on basophils, CD14 + monocytes, and neutrophils. Each sample is represented by one dot, and the mean is marked in red. One-way ANOVA with Bonferroni multiple comparison test was used. Source data are provided as a Source Data file.