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. 2021 May 21;6:35. doi: 10.1038/s41525-021-00199-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Analysis of diverse tissues identified four genes that passed an FDR correction for multiple testing in the TWAS and indicate that expression may modify ACT risk. Gene-level Z-scores, reflecting the number of standard deviations the mean expression of the gene (adjusted for the weight of each eQTL influencing expression of the gene) in ACT cases is from that of controls, across tissues where these genes were detected are plotted. b Association of top TWAS associated genes in tissues most relevant for ACT (i.e. heart and arterial). Z-score > 0 (green) indicates increased expression in ACT cases, while Z-score < 0 (purple) indicates decreased expression in these patients. c Gene interaction networks for the top TWAS associated genes identified using GeneMANIA.