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. 2021 May 21;12:3028. doi: 10.1038/s41467-021-23187-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Line and bar graphs represent interaction time between resident (test) and intruder mice exclusively initiated by resident mouse in one-minute intervals (line graphs, on the left) or over the total time (bar graphs, on the right) during a 5 min resident-intruder test in home cage for 4 (a), 10 (b), and 22 (c) months-old Fus^+/+ (black) and Fus^ΔNLS/+ (orange) male mice. Note that, young Fus^ΔNLS/+ mice demonstrated a trend towards an increased social interest for intruder mouse (a) while older mice interacted with intruders significantly longer then Fus^+/+ (b, c) showing an age-dependent impairment of social behavior–disinhibition. All values are represented as mean ± SEM. At 4 months, N = 9 for Fus^+/+ and N = 8 for Fus^ΔNLS/+ mice; At 10 months, N = 14 for Fus^+/+ and N = 14 for Fus^ΔNLS/+ mice; At 22 months, N = 8 for Fus^+/+ and N = 10 for Fus^ΔNLS/+ mice. Two-way repeated measures ANOVA followed by Sidak post-hoc test (p = 0.07 (4 months), p < 0.001 (10 months), and p = 0.007 (22 months) for genotype.effect); Two-sided Unpaired Student’s t-test for total time p = 0.07 (4 months), p < 0.001 (10 months), and p = 0.007 (22 months)). d, f Line graphs represent sociability in the three-chamber test measured as interaction time with novel mice across three trials for Fus^+/+(black) and Fus^ΔNLS/+ (orange) male mice at 4 (d), 10 (e), and 22 (f) months of age. Time exploring an empty cage (object) across trials is represented as dashed lines. At 4 months, N = 9 for Fus^+/+ and N = 8 for Fus^ΔNLS/+ mice; At 10 months, N = 14 for Fus^+/+ and N = 14 for Fus^ΔNLS/+ mice; At 22 months, N = 8 for Fus^+/+ and N = 9 for Fus^ΔNLS/+ mice. Data are presented as mean ± SEM. Three-way ANOVA with Newman Keuls post-hoc test for multiple comparisons, p = ns (4 months), p < 0.001 (10 months) and p = ns (22 months) for genotype effect). Source data are provided as a Source Data file.