Table 4.

Mutational analysis of the subgroup

Nr.	Age	Sex	Histological subtype	Location	Sample type	BRAF	NRAS	NF1	KIT	TERT Promoter	other mutations
1	45	F	LE - ALM	volar	U	V600E
2	56	F	LE - U	other	U	V600E
3	21	M	LE - SSM	dorsal	M	V600E
4	46	M	LE - NM	unknown	M	V600E
5	35	M	LE - NM	dorsal	U	V600E	Q61K			C250T	ARID1A G1375S
6	58	M	LE - ALM	unknown	P	V600E	A155V			C250T	EZH2 D185H
7	61	F	LE - U	unknown	P	V600E				CC242–3TT
8	54	F	LE - U	other	U	V600E				C250T
9	66	M	LE - ALM	other	U	V600E				CC228–9TT C250T	SMARCA4 F1142S
10	90	F	UE - NM	dorsal	U	V600E				C225T
11	72	F	LE - ALM	volar	U	V600E				CC228–9TT CC242–3TT
12	66	M	LE - ALM	volar	U	V600E					TERT R1086H, ARID1A N906K
13	39	F	LE - U	volar	M	V600E					PIK3CA I391M
14	71	M	LE - ALM	volar	U	V600E					SMARCA4 G101E, SMARCA4 R1640W
15	69	M	LE - SSM	other	U	V600E					ARID1A P1710S, ARID2 Q397L, CDKN2A R10G CDKN2A I11fs IDH1 A141fs IDH1 Y183C
16	80	F	LE - NM	volar	U		Q61R
17	79	F	LE - U	other	M		Q61H
18	76	F	LE - U	volar	M		Q61K
19	76	F	LE - SSM	volar	U		Q61R
20	67	F	LE - ALM	volar	U		G12S
21	60	F	LE - ALM	volar	P		Q61R	M1461E
22	75	M	LE - NM	volar	P		Q61R	V1308L
23	75	F	LE - ALM	other	P		G12D	N2128K			ARID1A R1202Q ARID2 M428I PTEN Y318D
24*	69	M	LE - ALM	volar	U		Q61R				BAP1 S473M ARID1A R1551C ARID1A P1568S TERT P313L
25	75	F	LE - ALM	other	P		G12D			CC228–9TT
26	64	M	LE - U	volar	M		Q61K			C250T
27	84	M	LE - NM	volar	P		Q61R				GNAQ R183G
28	72	F	LE - ALM	volar	U			L1109*
29	74	M	LE - ALM	unknown	U			T1565fs
30	68	M	LE - U	other	R			C152fs			ARID1A R1202Q
31	62	M	LE - ALM	volar	P			R1337W
32	71	M	LE - U	other	P				L576 P
33	82	F	LE - SSM	volar	P				K642 E
34	57	M	UE - U	other	U				A829 P	C250T
35	48	F	LE - NM	other	U					CC242–3TT
36	64	M	LE - ALM	other	P					C250T
37	63	M	LE - ALM	other	P					CC242–3TT
38	74	M	LE - U	volar	P						WT1 G317E
39	28	F	LE - ALM	other	U						IDH1 R222S
40	72	M	LE - NM	volar	P						TERT S803R
41	57	M	LE - U	other	M						MAP2K2 G286R WT1T221I SMARCA4 R842Q TP53 K120R
42	55	F	UE - ALM	other	U
43	34	M	LE - ALM	volar	P
44	75	M	LE - ALM	unknown	U
45	79	F	LE - U	volar	P
46	61	F	LE - ALM	volar	U
47	57	M	LE - U	dorsal	M
48	69	M	LE - ALM	volar	M
49	55	F	UE - ALM	other	U
50	61	F	LE - U	other	P

^*Only mutations with a frequency >20% are displayed due to the high number of identified mutations

Abbreviations: ALM, acral lentiginous melanoma; F, female; LE, lower extremity; M, male; Met, metastasis; NM, nodular melanoma, P, primary tumour; R, recurrence; SSM; superficial spreading melanoma; U, unknown; UE, upper extremity.