Table 6.

Known Functions of the Identified Novel Reference Genes

Gene name	Protein name	Function	Refs
DDB1	DNA damage-binding protein 1	Involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes	32–34
EDF1	Endothelial differentiation-related factor 1	Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1, and NR5A1. Regulates nitric oxide synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced CMs hypertrophy and lipid metabolism	38–41
KIAA1429 (VIRMA)	Protein virilizer homolog	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing	35,36
ZNF384	Zinc finger protein 384	Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7, and COL1A1 (by similarity)	37

Function obtained from UniProt knowledgebase. PPARG, peroxisome proliferator activated receptor gamma.