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. Author manuscript; available in PMC: 2021 May 22.
Published in final edited form as: Handb Clin Neurol. 2014;125:275–290. doi: 10.1016/B978-0-444-62619-6.00017-3

Table 17.1.

Primary and secondary brain regions that are targets of alcohol-related syndromes

Alcoholism-related syndrome Abbreviation Primary targeted region(s) Secondary targeted regions
Wernicke’s encephalopathy WE Mammillary bodies, periaqueductal gray matter, tissue surrounding third ventricle Dorsal medulla, tectal plates, olivary bodies, pons
Korsakoff’s syndrome KS Mammillary bodies, hippocampus, thalamus, orbitofrontal cortices Cerebellum, pons
Hepatic encephalopathy HE Globus pallidus, substantia nigra Corticospinal tract, cortex
Central pontine myelinolysis CPM Pons Basal ganglia, thalamus, cerebral gray–white-matter junctions
Alcoholic cerebellar degeneration ACD Cerebellum
Alcohol-related dementia ARD Frontal cortex
Marchiafava–Bignami disease MBD Corpus callosum Cortex