Table 1.

General characteristics of mice from each drug treatment group

Groups	Body Weight	Aorta	Heart	Kidney
	g	%
Vehicle	27.4 ± 2.4	0.23 ± 0.07	0.60 ± 0.13	1.14 ± 0.08
0.3 valsartan	26.2 ± 1.1	0.18 ± 0.07	0.60 ± 0.10	1.10 ± 0.05*
0.5 valsartan	28.5 ± 1.9	0.20 ± 0.05	0.50 ± 0.09	1.10 ± 0.08
1 valsartan	30.4 ± 3.5*	0.18 ± 0.04	0.45 ± 0.07*	1.12 ± 0.06
6 valsartan	30.7 ± 1.3*	0.14 ± 0.02*	0.44 ± 0.04*	1.17 ± 0.08
20 valsartan	30.0 ± 2.7	0.11 ± 0.02*	0.42 ± 0.07*	1.20 ± 0.09
1 sacubitril	26.6 ± 2.7	0.22 ± 0.08	0.66 ± 0.10	1.16 ± 0.08
6 sacubitril	29.2 ± 2.0	0.17 ± 0.05	0.63 ± 0.14	1.11 ± 0.06
9 sacubitril	28.0 ± 2.3	0.24 ± 0.070	0.43 ± 0.05*	1.04 ± 0.13
0.3 Val+ 1 Sac	26.8 ± 0.8	0.19 ± 0.04	0.57 ± 0.06	1.20 ± 0.04
0.5 Val+ 9 Sac	30.6 ± 3.0*	0.18 ± 0.05	0.45 ± 0.07*	1.06 ± 0.07

Tissue weights are expressed as a percentage of body weight. Data are means ± S.D.

^*P < 0.05 compared with vehicle.