Table 1.

Estimation of patients with severe uncontrolled asthma in Italy

#	Group of subjects	Estimation	Number of subjects (N)	Source
1	Italian population, ≥ 12 years	–	5,41,19,490	ISTAT 2019 [43]
2	Patients with asthma	6.10% of #1	33,01,289	[41]
3	Patients with asthma exemption code	36.29% of #2	11,97,821
4	Patients with spirometry (last 12 months)	27.74% of #3	3,32,281
5	Patients treated with ICS	46.95% of #4	1,55,997
6	Patients treated with high-dose ICS	43.05% of #5	67,151
7	Patients treated with high-dose ICS, adherent	57.20% of #6	38,410
8	Uncontrolled patients with ≥ 2 exacerbations/year*	47.57% of #7	18,270
9	Uncontrolled patients with severe asthma	0.04% of #1	21,649	[39]
10	Average number uncontrolled patients with severe asthma	Average of #8 and #9	19,960	Calculated

ICS inhaled corticosteroids, ISTAT italian institute of statistics

*Corresponding to 0.034% of the Italian population, ≥ 12 years (#1)